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After the initial two week period, carbohydrate intake is gradually increased until it reaches a level at which the dieter loses weight slowly and can reduce or eliminate the supplements. Once the target weight is reached, carbohydrate levels are again gradually increased until the dieter's weight becomes stable. Each of these carbohydrate levels varies from person to person. Dr. Atkins argues that many eating disorders are the result of hyperinsulinism, or excessive secretion of insulin, which, according to Atkins, causes food cravings and unstable blood sugar levels. Atkins claims that his diet stabilizes insulin and blood sugar levels, eliminating cravings and often reducing appetite.

A research study carried out by the Weight and Eating Disorders Program at the University of Pennsylvania, reported in May 2003 that the Atkins diet raised levels of HDL (or "good") cholesterol by an average of 11% and reduced the amount of triglycerides in the bloodstream by 17%. In the study, conventional dieters' HDL cholesterol raised by only 1.6% while their triglyceride levels did not improve significantly. Weight loss was also statistically greater in the Atkins dieters after three and six months compared with the conventional dieters (although this did not remain statistically significant after a year). The study followed the diets of 63 obese men and women. (See New Scientist, May 21 2003) Two other large-scale studies are planned, one funded by Atkins's nonprofit foundation.

The Atkins Diet and other low-carb plans have shown poor results in the long-term. Considering the health risks associated with the regimen, the Atkins Diet seems like a poor choice when there are so many sensible alternatives.