Different types of cancer
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Malignant tumors such as carcinoma or sarcoma, lymphoma or leukemia originate from a cell or a group of cells in a multicellular organism that has several distinct properties:
- evading apoptosis
- Unlimited Growth Potential
- self-sufficiency of growth factors
- insensitivity to anti-growth factors
- increased cell division rate
- altered differentiation (specialization) ability
- no ability for contact inhibition
- ability to invade neighbouring tissue
- ability to build metastases
- ability to promote blood vessel growth (angiogenesis)
In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:
- Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
- Altered morphology.
- Building of cellular clusters (Foci).
- Loss of contact inhibition.
- Low or no need for growth factors.
Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.
In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.
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- CancerEducation
Disseminates educational programming in a multimedia electronic clips format. Aimed at both a lay and professional audience. - Cancer Leadership Council
A patient-centered forum of national advocacy organizations addressing public policy issues. - Cancer Nutrition Center
Explores the link between tumors and nutrition. Offers dietary advice for patients. - Imperial Cancer Research Fund
News and information about the prevention, diagnosis and treatment of this condition. A UK charity site. - On Top Of Cancer
Links-based guide to Internet resource.