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Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.
For most of the cancers, it cannot be told which event was the initial cause. However, with molecular biology, it is possible to characterize the mutations within a tumor, and to a certain extent predict its behavior. For example, about half of the tumors are deficient in the tumor suppressor gene p53, also known as "the guardian of the genome". This is associated with poor prospects for the patient, since those tumor cells are unlikely to go into apoptosis (programmed cell death) after they are damaged by therapy. There are more mutations that make a tumor more malignant. Telomerase mutations enable a tumor cell to divide indefinitely. Other mutations enable the tumor to grow new blood vessels to feed it, or to detach from the surrounding tissue, spreading to other parts of the body.
The term cancer is very broad and covers many different illnesses including:
- Carcinoma (arising from epithelial cells)
- Bladder carcinoma
- Breast cancer
- Cervical cancer
- Colorectal cancer (includes colon, rectum, anus, and appendix)
- Esophageal cancer
- Endometrial cancer (uterus)
- Hepatocellular carcinoma (liver)
- Laryngeal cancer
- Lung cancer
- Oral cancer
- Ovarian cancer
- Pancreatic cancer
- Prostate cancer
- Renal cell carcinoma (kidney)
- Skin cancer
- Stomach cancer
- Testicular cancer
- Thyroid cancer
- Sarcoma (arising from connective tissue and related)
- Gastrointestinal stromal cell tumor (GIST)
- Rhabdomyosarcoma (muscle)
- Osteosarcoma (bone)
- Hematological malignancies (blood and bone marrow)
- Leukemia
- Lymphomas
- Hodgkin's disease
- Non-Hodgkin's lymphoma
- Multiple myeloma
- Miscellaneous
- Brain tumor
- Melanoma, Moles and dysplastic nevi
- Teratoma
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- CancerFit
Details the activities of a program at the Sedona Racquet Club in Arizona. Designed to help survivors maintain good physical, emotional and spiritual fitness. - MedicineNet: Cancer
Presents information such as prevention and treatment side-effects. Also gives resources including links, articles and support groups. - Cancer.com
Provides treatment information, support group listings, online education, decision-making resources, physician locator services and risk assessment tools. - Cancer Advice UK
Advice and information about diagnosis and treatment issues. Includes leaflets, book suggestions, links and support groups. - Cancer Leadership Council
A patient-centered forum of national advocacy organizations addressing public policy issues.