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Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.

For most of the cancers, it cannot be told which event was the initial cause. However, with molecular biology, it is possible to characterize the mutations within a tumor, and to a certain extent predict its behavior. For example, about half of the tumors are deficient in the tumor suppressor gene p53, also known as "the guardian of the genome". This is associated with poor prospects for the patient, since those tumor cells are unlikely to go into apoptosis (programmed cell death) after they are damaged by therapy. There are more mutations that make a tumor more malignant. Telomerase mutations enable a tumor cell to divide indefinitely. Other mutations enable the tumor to grow new blood vessels to feed it, or to detach from the surrounding tissue, spreading to other parts of the body.

In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.

  • World Oncology Network
    World directory of cancer specialists and hematologists.
  • MCW Healthlink: Cancer
    Medical College of Wisconsin Physicians and Clinics resource which provides news articles and information about recent developments.
  • The World Against Cancer
    A conduit source consisting primarily of multi-lingual search engines.
  • The Cancer Letter
    Periodical which supplies news and current information about the state of research and treatment.
  • Wikicities: Cancer
    An open-publishing wiki portal for those interested in this topic. Available for viewing or editing.