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Medical conditions often require the use of a special diet that either contains or lacks certain chemicals. A person who has diabetes is often on a diet designed to carefully regulate their blood sugar level, sufferers of celiac disease must follow a gluten-free diet, the lactose-intolerant omit milk and dairy products, and people with kidney disease must follow a strict low-sodium diet to ease the strain on their kidneys.

Diets affect the "energy in" component of the energy balance by limiting or altering the distribution of foods. Techniques the affect the appetite can limit energy intake by affecting the desire to overeat. This can be attempted by focusing on foods that are filling, through the use of certain appetite supressing drugs, or through activities such as mild exercise, that affect appetite. Other techniques address habitual or emotional eating.

VLCD's can be very successful but only when used over a 6-12 week period. Because the body is essentially starving, it is burning up its fat stores and lowering its metabolic rate. As soon as the diet ceases and normal food is consumed again, there is an immediate increase in weight. Short-term use of VLCDs (1-4 weeks) will have little, if any, benefit for the dieter as the increase in weight will negate the weight lost in the first place. Once the full course of the diet is finished, it is up to the successful dieter to maintain their current weight via exercise and sensible eating, otherwise they will put on weight again. VLCD's put a great deal of strain on a person's body, and should only be undertaken with medical consultation.

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