Gastric cancer

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Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.

Treatment of cancer typically involves surgery to remove tumors and nearby lymph nodes to which the cancer may have spread, combined with radiation therapy and/or chemotherapy. The latter two target cells in the body that are rapidly dividing. This includes the cancer cells but also certain healthy ones, which is the reason for the severe side effects of these treatments.

In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:

  • Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
  • Altered morphology.
  • Building of cellular clusters (Foci).
  • Loss of contact inhibition.
  • Low or no need for growth factors.

Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.

  • DIPEx: Cancer
    Includes audio and video interviews of patient experiences.
  • Wikicities: Cancer
    An open-publishing wiki portal for those interested in this topic. Available for viewing or editing.
  • Cancer Page
    Information and community resources including chat rooms, message boards, physician directory and clinical trials.
  • CancerEducation
    Disseminates educational programming in a multimedia electronic clips format. Aimed at both a lay and professional audience.
  • About.com: Cancer
    Presents general overview information on many of the main kinds of tumors. Includes news, doctor search, glossary and access to support hotlines.