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Critics of low-carbohydrate diets also point out that from an environmental point of view an increased consumption of animal protein places a great burden on the world's natural resources and is not sustainable. They also point out that the explosive growth in global population over the last few centuries was only possible because of grain crops.

A study conducted in 1965 at the Oakland (California) Naval Hospital used a diet of 1000 calories per day, high in fat and limiting carbohydrates to 10 grams (40 calories) daily. Over a ten-day period, subjects on this diet lost more body fat than did a group who fasted completely. (Benoit et. al. 1965). Some advocates of low-carbohydrate diets have termed this the metabolic advantage of such diets.

In 2004, a Canadian court ruled that foods sold in Canada could not be marketed with reduced or eliminated carbohydrate content as a selling point because carbohydrates were determined not to be a health risk, and that existing "low carb" and "no carb" packaging would have to be phased out by 2006.