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The Atkins diet has generally been considered by most medical and nutritional experts to be unsound or even quackery. Opponents of the diet mention that the initial weight loss upon starting on this diet is a phenomenon common with most diets, and is due to reduction in stored glycogen and related water in muscles, not fat loss. They claim that no evidence has surfaced that any diet will cause weight loss unless it reduces calories below the maintenance level. Reports have also indicated that successful weight loss due to the Atkins diet has been the result of fewer kilojoules (calories) being consumed by the dieter, rather than the lack of carbohydrates. [2]

There are reports indicating that studies have shown benefits for heartstroke as well as diabetic patients, and that many experts are already discussing a low carb nutrition for diabetic patients who may then be able to live their lives without any insulin. Like any diet, the health effects will depend a great deal on the food choices one makes to meet the macronutrient requirements specified by the diet.

A research study carried out by the Weight and Eating Disorders Program at the University of Pennsylvania, reported in May 2003 that the Atkins diet raised levels of HDL (or "good") cholesterol by an average of 11% and reduced the amount of triglycerides in the bloodstream by 17%. In the study, conventional dieters' HDL cholesterol raised by only 1.6% while their triglyceride levels did not improve significantly. Weight loss was also statistically greater in the Atkins dieters after three and six months compared with the conventional dieters (although this did not remain statistically significant after a year). The study followed the diets of 63 obese men and women. (See New Scientist, May 21 2003) Two other large-scale studies are planned, one funded by Atkins's nonprofit foundation.