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Proponents of the diet mention that low-carbohydrate diets have been the subject of heated debate in medical circles for three decades [1], but are still "damned knowledge", so much so that until recently no serious research has been done on Atkins or other low carbohydrate diets. They mention that a few small research projects, as well as a great deal of anecdotal evidence, have shown such diets to help participants lose weight.

The Atkins Nutritional Approach, popularly known as the Atkins Diet or just Atkins, is a trendy but controversial high-protein, high-fat, low-carbohydrate diet popularized by Dr. Robert Atkins (1930-2003) in a series of books, starting with Dr. Atkins' Diet Revolution.

A research study carried out by the Weight and Eating Disorders Program at the University of Pennsylvania, reported in May 2003 that the Atkins diet raised levels of HDL (or "good") cholesterol by an average of 11% and reduced the amount of triglycerides in the bloodstream by 17%. In the study, conventional dieters' HDL cholesterol raised by only 1.6% while their triglyceride levels did not improve significantly. Weight loss was also statistically greater in the Atkins dieters after three and six months compared with the conventional dieters (although this did not remain statistically significant after a year). The study followed the diets of 63 obese men and women. (See New Scientist, May 21 2003) Two other large-scale studies are planned, one funded by Atkins's nonprofit foundation.