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Atkins recommends restriction of the intake of carbohydrates in order to switch the body metabolism from using glucose as the fuel to burning fat (both dietary and stored fat). This process of lipolysis begins when the body enters the state of ketosis as a consequence of running out of carbohydrates to burn.

Another argument is that many countries whose traditional diets are high in carbohydrates and low in fat (for example, Japan) have significantly low rates of obesity. This seems to directly contradict Atkins' claims.

Proponents of the diet mention that low-carbohydrate diets have been the subject of heated debate in medical circles for three decades [1], but are still "damned knowledge", so much so that until recently no serious research has been done on Atkins or other low carbohydrate diets. They mention that a few small research projects, as well as a great deal of anecdotal evidence, have shown such diets to help participants lose weight.