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The Very Low Calorie Diet, or VLCD, is a special diet to be undertaken with medical supervision. It offers rapid fat loss over a short timeframe, but can be dangerous for some people. It consists of the consumption of a special powder mixed in with 200-300ml of water to be taken three times a day. The drink, similar to a milkshake, provides approximately 1914Kj (456 Cal) of energy per day when consumed at breakfast, lunch and dinner. It contains all necessary vitamins and minerals, although there is a risk of overdosing on Selenium if a person consumes more than they should (more than three times per day). VLCD's should only be used for dieting when a person's Body mass index exceeds 30. In addition, at least 2 litres of water must be consumed per day and a person should consider using fibre supplements regularly. Without this, the person risks severe constipation.

VLCD's can be very successful but only when used over a 6-12 week period. Because the body is essentially starving, it is burning up its fat stores and lowering its metabolic rate. As soon as the diet ceases and normal food is consumed again, there is an immediate increase in weight. Short-term use of VLCDs (1-4 weeks) will have little, if any, benefit for the dieter as the increase in weight will negate the weight lost in the first place. Once the full course of the diet is finished, it is up to the successful dieter to maintain their current weight via exercise and sensible eating, otherwise they will put on weight again. VLCD's put a great deal of strain on a person's body, and should only be undertaken with medical consultation.

Diets affect the "energy in" component of the energy balance by limiting or altering the distribution of foods. Techniques the affect the appetite can limit energy intake by affecting the desire to overeat. This can be attempted by focusing on foods that are filling, through the use of certain appetite supressing drugs, or through activities such as mild exercise, that affect appetite. Other techniques address habitual or emotional eating.

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