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Medical conditions often require the use of a special diet that either contains or lacks certain chemicals. A person who has diabetes is often on a diet designed to carefully regulate their blood sugar level, sufferers of celiac disease must follow a gluten-free diet, the lactose-intolerant omit milk and dairy products, and people with kidney disease must follow a strict low-sodium diet to ease the strain on their kidneys.

Diets affect the "energy in" component of the energy balance by limiting or altering the distribution of foods. Techniques the affect the appetite can limit energy intake by affecting the desire to overeat. This can be attempted by focusing on foods that are filling, through the use of certain appetite supressing drugs, or through activities such as mild exercise, that affect appetite. Other techniques address habitual or emotional eating.

The Very Low Calorie Diet, or VLCD, is a special diet to be undertaken with medical supervision. It offers rapid fat loss over a short timeframe, but can be dangerous for some people. It consists of the consumption of a special powder mixed in with 200-300ml of water to be taken three times a day. The drink, similar to a milkshake, provides approximately 1914Kj (456 Cal) of energy per day when consumed at breakfast, lunch and dinner. It contains all necessary vitamins and minerals, although there is a risk of overdosing on Selenium if a person consumes more than they should (more than three times per day). VLCD's should only be used for dieting when a person's Body mass index exceeds 30. In addition, at least 2 litres of water must be consumed per day and a person should consider using fibre supplements regularly. Without this, the person risks severe constipation.

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