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A study conducted in 1965 at the Oakland (California) Naval Hospital used a diet of 1000 calories per day, high in fat and limiting carbohydrates to 10 grams (40 calories) daily. Over a ten-day period, subjects on this diet lost more body fat than did a group who fasted completely. (Benoit et. al. 1965). Some advocates of low-carbohydrate diets have termed this the metabolic advantage of such diets.

Critics of low-carbohydrate diets also point out that from an environmental point of view an increased consumption of animal protein places a great burden on the world's natural resources and is not sustainable. They also point out that the explosive growth in global population over the last few centuries was only possible because of grain crops.

Critics contend that low carbohydrate diets are not without harmful side effects. Very low carbohydrate consumption can lead to the metabolic state called ketosis, which may cause headaches, tiredness, nausea, dehydration, dizziness, and an unusual sweet-smelling breath odor. The lowered intake of dietary fiber that often accompanies dramatically reduced carbohydrate intake (such as in the Induction stage of the Atkins diet) can result in constipation if not supplemented.