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Replacement of calories from carbohydrates with meat may result in high consumption of saturated fat and cholesterol, which many authorities believe will increase the risk of heart disease. Moreover, it has been hypothesised that the kidneys can become overworked and that a related change in blood acidity can lead to bone loss, but trials testing the hypothesis have found no evidence of kidney damage or loss of bone.

Critics of low-carbohydrate diets also point out that from an environmental point of view an increased consumption of animal protein places a great burden on the world's natural resources and is not sustainable. They also point out that the explosive growth in global population over the last few centuries was only possible because of grain crops.

Under these various dietary programs, foods containing carbohydrates (like sugar, grains, and starches) are limited or replaced in favor of foods containing more protein and fat. Vegetables, though classified as carbohydrates, are thought to be far healthier than grain-based carbohydrates. Programs such as the South Beach, Atkins and Zone diets, are claimed to "work" because they reduce insulin levels, which in turn causes the body to burn its fat for energy.