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A study conducted in 1965 at the Oakland (California) Naval Hospital used a diet of 1000 calories per day, high in fat and limiting carbohydrates to 10 grams (40 calories) daily. Over a ten-day period, subjects on this diet lost more body fat than did a group who fasted completely. (Benoit et. al. 1965). Some advocates of low-carbohydrate diets have termed this the metabolic advantage of such diets.

Critics contend that low carbohydrate diets are not without harmful side effects. Very low carbohydrate consumption can lead to the metabolic state called ketosis, which may cause headaches, tiredness, nausea, dehydration, dizziness, and an unusual sweet-smelling breath odor. The lowered intake of dietary fiber that often accompanies dramatically reduced carbohydrate intake (such as in the Induction stage of the Atkins diet) can result in constipation if not supplemented.

Low-carbohydrate diets or low carb diets, are food diet programs for weight loss and dietary health that advocate restricted carbohydrate consumption, based on research that ties carbohydrate consumption with increased blood insulin levels, and increased insulin with obesity.