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Replacement of calories from carbohydrates with meat may result in high consumption of saturated fat and cholesterol, which many authorities believe will increase the risk of heart disease. Moreover, it has been hypothesised that the kidneys can become overworked and that a related change in blood acidity can lead to bone loss, but trials testing the hypothesis have found no evidence of kidney damage or loss of bone.

A study conducted in 1965 at the Oakland (California) Naval Hospital used a diet of 1000 calories per day, high in fat and limiting carbohydrates to 10 grams (40 calories) daily. Over a ten-day period, subjects on this diet lost more body fat than did a group who fasted completely. (Benoit et. al. 1965). Some advocates of low-carbohydrate diets have termed this the metabolic advantage of such diets.

Advocates of the diet counter environmental criticisms by arguing that the majority of grain farm land was formerly poor quality pasture fit only for raising livestock and that it has been turned to grain production only through massive government subsidy and the use of environmentally questionable fertilizers and pesticides.