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Under these various dietary programs, foods containing carbohydrates (like sugar, grains, and starches) are limited or replaced in favor of foods containing more protein and fat. Vegetables, though classified as carbohydrates, are thought to be far healthier than grain-based carbohydrates. Programs such as the South Beach, Atkins and Zone diets, are claimed to "work" because they reduce insulin levels, which in turn causes the body to burn its fat for energy.

In 2004, a Canadian court ruled that foods sold in Canada could not be marketed with reduced or eliminated carbohydrate content as a selling point because carbohydrates were determined not to be a health risk, and that existing "low carb" and "no carb" packaging would have to be phased out by 2006.

Critics contend that low carbohydrate diets are not without harmful side effects. Very low carbohydrate consumption can lead to the metabolic state called ketosis, which may cause headaches, tiredness, nausea, dehydration, dizziness, and an unusual sweet-smelling breath odor. The lowered intake of dietary fiber that often accompanies dramatically reduced carbohydrate intake (such as in the Induction stage of the Atkins diet) can result in constipation if not supplemented.