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Advocates point to scientific trials demonstrating the efficacy and safety of low carb diets. Several independent clinical trials have shown that low carb diets can successfully be used to lose weight. These trials found that, in the short term, risk factors for heart disease and diabetes — such as blood serum cholesterol and insulin levels — tended to improve in spite of increased consumption of saturated fat and cholesterol. The trials were of short duration, and were not able to assess the long-term health effects of the diet.

Under these various dietary programs, foods containing carbohydrates (like sugar, grains, and starches) are limited or replaced in favor of foods containing more protein and fat. Vegetables, though classified as carbohydrates, are thought to be far healthier than grain-based carbohydrates. Programs such as the South Beach, Atkins and Zone diets, are claimed to "work" because they reduce insulin levels, which in turn causes the body to burn its fat for energy.

The recent rise in western obesity rates has coincided with a widespread belief in low-fat, high-carbohydrate as a healthy way of eating. By contrast traditional, high-fat French cooking has led to a much lower incidence of obesity, morbid obesity and chronic heart disease than the high-sugar American diet, despite overall energy intake and exercise levels being the same.