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The South Beach diet was developed by a cardiologist, Arthur Agatston, practicing in the Miami, Florida area. The diet first appeared in a book of the same name, published by Rodale Press.

This diet emphasizes making a permanent change in one's way of eating. It suggests whole grains and large amounts of vegetables, along with adequate amounts of mono- and polyunsaturated fats, including Omega-3 oils. It discourages the eating of overly refined foods, particularly refined flours and sugars.

In the initial phase, lasting a few weeks, dieters attempt to eliminate cravings for "bad carbohydrates" by eating no grains or fruits. After this phase, grain-based foods and fruits are gradually returned to the diet, although in smaller amounts than were likely eaten before beginning the diet, and with a concentration on foods with a low glycemic index, such as whole grains instead of refined flour. By the time the dieter has lost the desired weight, they should be having three servings of whole grains and three servings of fruit a day. The more strict Phase 1 may be reinstituted if the person feels they have developed cravings for foods they shouldn't have.