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The Very Low Calorie Diet, or VLCD, is a special diet to be undertaken with medical supervision. It offers rapid fat loss over a short timeframe, but can be dangerous for some people. It consists of the consumption of a special powder mixed in with 200-300ml of water to be taken three times a day. The drink, similar to a milkshake, provides approximately 1914Kj (456 Cal) of energy per day when consumed at breakfast, lunch and dinner. It contains all necessary vitamins and minerals, although there is a risk of overdosing on Selenium if a person consumes more than they should (more than three times per day). VLCD's should only be used for dieting when a person's Body mass index exceeds 30. In addition, at least 2 litres of water must be consumed per day and a person should consider using fibre supplements regularly. Without this, the person risks severe constipation.

Medical conditions often require the use of a special diet that either contains or lacks certain chemicals. A person who has diabetes is often on a diet designed to carefully regulate their blood sugar level, sufferers of celiac disease must follow a gluten-free diet, the lactose-intolerant omit milk and dairy products, and people with kidney disease must follow a strict low-sodium diet to ease the strain on their kidneys.

Certain religions, including Judaism and Islam, also impose strict restrictions on diet, but these are not usually thought of as "dieting".

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