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Medical conditions often require the use of a special diet that either contains or lacks certain chemicals. A person who has diabetes is often on a diet designed to carefully regulate their blood sugar level, sufferers of celiac disease must follow a gluten-free diet, the lactose-intolerant omit milk and dairy products, and people with kidney disease must follow a strict low-sodium diet to ease the strain on their kidneys.

The only "safe" method of weight loss is to eat a sensible healthy diet with a moderately decreased caloric intake from your norm, and to increase exercise gradually until weight loss results. It should be noted that people may follow these guidelines and not actually lose weight, but may see health improvements.

The Very Low Calorie Diet, or VLCD, is a special diet to be undertaken with medical supervision. It offers rapid fat loss over a short timeframe, but can be dangerous for some people. It consists of the consumption of a special powder mixed in with 200-300ml of water to be taken three times a day. The drink, similar to a milkshake, provides approximately 1914Kj (456 Cal) of energy per day when consumed at breakfast, lunch and dinner. It contains all necessary vitamins and minerals, although there is a risk of overdosing on Selenium if a person consumes more than they should (more than three times per day). VLCD's should only be used for dieting when a person's Body mass index exceeds 30. In addition, at least 2 litres of water must be consumed per day and a person should consider using fibre supplements regularly. Without this, the person risks severe constipation.

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