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A large part of this mechanism was clarified by Dr Michael S. Brown and Dr Joseph L. Goldstein, who received the Nobel Prize in Physiology or Medicine for their work in 1985.

In conditions featuring elevated LDL, cholesterol often forms plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease.

As today's testing methods determine LDL ("bad") and HDL ("good") cholesterol separetely, this simplistic view has become somewhat outdated. The desirable LDL level is considered to be 75-130 mg/dl (1.9-3.3 mmol/L), and a ratio of total cholesterol to HDL—arguably the most useful measure—of less than 5:1 is thought to be healthy.

  • Veritas Medicine
    Clinical trial listings for high cholesterol. Perform a personalized search to find ongoing clinical trials that match your needs.
  • How Stuff Works
    Doctor-written seven-part description of cholesterol and how to avoid its health problems.
  • Eat Fat, Be Healthy
    Information about genetically-caused heart disease due to small-particle LDL syndrome. Includes questions and answers, book excerpt and cardiac risk quiz.
  • WebMDHealth: Cholesterol Management Health Center
    Consumer health site for cholesterol, written and reviewed by doctors.
  • Living With Cholesterol: AHA
    Information for understanding the facts and reducing your risk factor of heart disease and stroke. Recipes available.