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Hair is an outgrowth of the epidermis in mammals. Hair is a characteristic of all mammals, though in some species hair is absent at certain stages of life.

Among humans, nature selected for little body hair as part of a set of adaptations including bipedal locomotion and an upright posture. Bipedal locomotion is extremely inefficient, and many animals can outrun human beings for short periods of time; such animals, however, are inefficient radiators of heat, and cannot run for long periods of time. Thus, human hunters must be able to chase animals for long periods of time, and must therefore have an efficient mechanism for radiating body heat. Upright posture, which exposes less surface area of the body to direct solar radiation, and subcutaneous sweat glands, which operate best with an absence of hair.

Hair is a biological polymer; over 90% of its dry weight is made up of proteins called keratins. Under normal conditions, human hair contains around 10% water, which modifies its mechanical properties considerably. Hair proteins are held together by disulfide bonds, from the amino acid cysteine. These links are very robust; for example, virtually intact hair has been recovered from ancient Egyptian tombs. Different parts of the hair have different cysteine levels, leading to harder or softer material.