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Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.
In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:
- Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
- Altered morphology.
- Building of cellular clusters (Foci).
- Loss of contact inhibition.
- Low or no need for growth factors.
Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.
Treatment of cancer typically involves surgery to remove tumors and nearby lymph nodes to which the cancer may have spread, combined with radiation therapy and/or chemotherapy. The latter two target cells in the body that are rapidly dividing. This includes the cancer cells but also certain healthy ones, which is the reason for the severe side effects of these treatments.
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Offers patients and professionals information about chemotherapy-induced nausea and vomiting. - Nexcura: Cancer Facts
Provides current information and access to a clinical trials profiler. - EMedicine Health: What You Need To Know
Consumer health resource center providing general information on cancer prevention, symptoms and treatment. - People Living With Cancer
Patient information from the American Society of Clinical Oncology. - CancerDirect
Patient consultation service offering treatment advice, online second opinions and oncologist referral for individual disease.