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Wellness can include using scientifically-based tests and practices to maintain health, as in checking cholesterol, blood pressure, glucose, and other body indicators. Or it can include unproven practices, such as avoiding certain foods or taking certain vitamins or alternative medicines.

Wellness refers generally to the state of being healthy, but by the late 20th century, became, as well, a description of the interest in the more affluent nations to adopt behaviors which prolong and enhance the state of being healthy, and by extension, the lifespan itself.

The subjective nature of "wellness" can be illustrated by the hypothetical example of an individual who avoids food additives and is selective in choosing foods to prolong health, but thinks nothing of getting in a car and driving hundreds of miles. Statistically, the known risk of mortality or morbidity from automobile usage is far greater than the risk of mortality or morbidity from food additives, but avoiding certain foods and food additives feels "healthy," whereas avoiding automobile use feels merely inconvenient.