Brain cancer
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In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:
- Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
- Altered morphology.
- Building of cellular clusters (Foci).
- Loss of contact inhibition.
- Low or no need for growth factors.
Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.
In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.
Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.
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- EMedicine Health: Cancer Symptoms
Consumer health resource center providing information on common symptoms. - Cellscience: A-Z Cancer Directory
Links-based listing in areas such as research, hospitals, charities, funding and education. - People Living With Cancer
Patient information from the American Society of Clinical Oncology. - Topix.net: Cancer News
Headline news and content on related issues. - DIPEx: Cancer
Includes audio and video interviews of patient experiences.