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Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.

Cancers are capable of spreading through the body by two mechanisms: local invasion and distant metastasis. Invasion refers to the direct migration and penetration by cancer cells into neighboring tissues. Metastasis refers to the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through the bloodstream, and then invade normal tissues elsewhere in the body. Cancer is most deadly when it metastasizes.

For most of the cancers, it cannot be told which event was the initial cause. However, with molecular biology, it is possible to characterize the mutations within a tumor, and to a certain extent predict its behavior. For example, about half of the tumors are deficient in the tumor suppressor gene p53, also known as "the guardian of the genome". This is associated with poor prospects for the patient, since those tumor cells are unlikely to go into apoptosis (programmed cell death) after they are damaged by therapy. There are more mutations that make a tumor more malignant. Telomerase mutations enable a tumor cell to divide indefinitely. Other mutations enable the tumor to grow new blood vessels to feed it, or to detach from the surrounding tissue, spreading to other parts of the body.

  • The World Against Cancer
    A conduit source consisting primarily of multi-lingual search engines.
  • A Notebook Guide For Newly Diagnosed Cancer Patients
    Information for people who have just received the diagnosis. Includes links, a message board and details about the author.
  • CancerFit
    Details the activities of a program at the Sedona Racquet Club in Arizona. Designed to help survivors maintain good physical, emotional and spiritual fitness.
  • Cancerlinksusa.com
    Information and links for all types of tumors.
  • ChemoCare
    Scott Hamilton’s chemotherapy site offers general treatment information for cancer patients. Sponsored by Ortho Biotech.