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For most of the cancers, it cannot be told which event was the initial cause. However, with molecular biology, it is possible to characterize the mutations within a tumor, and to a certain extent predict its behavior. For example, about half of the tumors are deficient in the tumor suppressor gene p53, also known as "the guardian of the genome". This is associated with poor prospects for the patient, since those tumor cells are unlikely to go into apoptosis (programmed cell death) after they are damaged by therapy. There are more mutations that make a tumor more malignant. Telomerase mutations enable a tumor cell to divide indefinitely. Other mutations enable the tumor to grow new blood vessels to feed it, or to detach from the surrounding tissue, spreading to other parts of the body.
The field of medicine concerned with the treatment of cancer is oncology. Cancer has become an important problem with the rise in life expectancy, as the abovementioned mutations become more likely the longer a person lives. Though great progress in treatment has been made, most cancers in advanced stages remain incurable and ultimately fatal.
In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.
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- Cancer Lynx
An online 'zine for patients and professionals. - CancerExperts MD
Physcians located in Boston offer second opinions and personalized case reviews. Provides an online ask-a-doctor service. - Hematology Oncology News & Issues
Headline news and articles for cancer professionals and patients. - Cancer Nutrition Center
Explores the link between tumors and nutrition. Offers dietary advice for patients. - Cancer Forums
Online discussions on various types of cancers. Includes topics such as coping, support, clinical trials and treatment options.