Constellation cancer

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Malignant tumors such as carcinoma or sarcoma, lymphoma or leukemia originate from a cell or a group of cells in a multicellular organism that has several distinct properties:

evading apoptosis
Unlimited Growth Potential
self-sufficiency of growth factors
insensitivity to anti-growth factors
increased cell division rate
altered differentiation (specialization) ability
no ability for contact inhibition
ability to invade neighbouring tissue
ability to build metastases
ability to promote blood vessel growth (angiogenesis)

For most of the cancers, it cannot be told which event was the initial cause. However, with molecular biology, it is possible to characterize the mutations within a tumor, and to a certain extent predict its behavior. For example, about half of the tumors are deficient in the tumor suppressor gene p53, also known as "the guardian of the genome". This is associated with poor prospects for the patient, since those tumor cells are unlikely to go into apoptosis (programmed cell death) after they are damaged by therapy. There are more mutations that make a tumor more malignant. Telomerase mutations enable a tumor cell to divide indefinitely. Other mutations enable the tumor to grow new blood vessels to feed it, or to detach from the surrounding tissue, spreading to other parts of the body.

Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.

CancerEducation
Disseminates educational programming in a multimedia electronic clips format. Aimed at both a lay and professional audience.
CancerSupportChat.org
Presents access to online discussion, chat and support.
NetHealthBook: Cancer
Symptoms, diagnostic tests and treatments of the most common cancers are described.
MyOwnBiopsy
Provides "translations" of cancer pathology reports from medical jargon into understandable lay terms.
MCW Healthlink: Cancer
Medical College of Wisconsin Physicians and Clinics resource which provides news articles and information about recent developments.

Constellation cancer