Lung cancer vaccine

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Malignant tumors such as carcinoma or sarcoma, lymphoma or leukemia originate from a cell or a group of cells in a multicellular organism that has several distinct properties:

evading apoptosis
Unlimited Growth Potential
self-sufficiency of growth factors
insensitivity to anti-growth factors
increased cell division rate
altered differentiation (specialization) ability
no ability for contact inhibition
ability to invade neighbouring tissue
ability to build metastases
ability to promote blood vessel growth (angiogenesis)

In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:

Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
Altered morphology.
Building of cellular clusters (Foci).
Loss of contact inhibition.
Low or no need for growth factors.

Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.

In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.

DIPEx: Cancer
Includes audio and video interviews of patient experiences.
InteliHealth: Cancer
Medical information, articles and news covering a variety of tumors and related issues.
AtCancer
Gives access to a MEDLINE-related search engine, as well as to reference links.
Manage CINV
Offers patients and professionals information about chemotherapy-induced nausea and vomiting.
AllExperts Oncology Q&A
Comprehensive directory of cancer experts volunteering to answer both general and disease-specific questions.

Lung cancer vaccine