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Malignant tumors such as carcinoma or sarcoma, lymphoma or leukemia originate from a cell or a group of cells in a multicellular organism that has several distinct properties:
- evading apoptosis
- Unlimited Growth Potential
- self-sufficiency of growth factors
- insensitivity to anti-growth factors
- increased cell division rate
- altered differentiation (specialization) ability
- no ability for contact inhibition
- ability to invade neighbouring tissue
- ability to build metastases
- ability to promote blood vessel growth (angiogenesis)
Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.
In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:
- Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
- Altered morphology.
- Building of cellular clusters (Foci).
- Loss of contact inhibition.
- Low or no need for growth factors.
Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.
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- Cancer Options UK
Designed to help patients and families find appropriate treatment options and services. Provides access to a nurse specialist. - InteliHealth: Cancer
Medical information, articles and news covering a variety of tumors and related issues. - Ladies Home Journal: Cancer
Links to articles about skin and breast tumors. - Cancer Page
Information and community resources including chat rooms, message boards, physician directory and clinical trials. - CancerNausea.com
Presents information to help manage nausea and vomiting caused by chemotherapy or radiation treatments.