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In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.
The field of medicine concerned with the treatment of cancer is oncology. Cancer has become an important problem with the rise in life expectancy, as the abovementioned mutations become more likely the longer a person lives. Though great progress in treatment has been made, most cancers in advanced stages remain incurable and ultimately fatal.
In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:
- Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
- Altered morphology.
- Building of cellular clusters (Foci).
- Loss of contact inhibition.
- Low or no need for growth factors.
Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.
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- Cancerlinksusa.com
Information and links for all types of tumors. - CancerFit
Details the activities of a program at the Sedona Racquet Club in Arizona. Designed to help survivors maintain good physical, emotional and spiritual fitness. - The World Against Cancer
A conduit source consisting primarily of multi-lingual search engines. - CancerCare
Topics of interest to patients and their families including treatment side-effects, pain control, nutrition and bereavement. - InteliHealth: Cancer
Medical information, articles and news covering a variety of tumors and related issues.