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Malignant tumors such as carcinoma or sarcoma, lymphoma or leukemia originate from a cell or a group of cells in a multicellular organism that has several distinct properties:

  • evading apoptosis
  • Unlimited Growth Potential
  • self-sufficiency of growth factors
  • insensitivity to anti-growth factors
  • increased cell division rate
  • altered differentiation (specialization) ability
  • no ability for contact inhibition
  • ability to invade neighbouring tissue
  • ability to build metastases
  • ability to promote blood vessel growth (angiogenesis)

Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.

A cell that degenerates into a tumor cell does usually not acquire all these properties at once, but its daughter cells are selected to build them. This process is called cellular evolution. A first step in the development of a tumor cell is usually a small change in the DNA, often a point mutation, which leads, among other things, to a genetic instability of the cell. The instability increases to a point where the cell loses whole chromosomes, or has double ones. Also, the DNA methylation pattern of the cell changes, activating and deactivating genes more or less at random. Cells that divide at a high rate, such as stem cells, show a higher risk of becoming tumor cells than those which divide less or not at all, for example neurons. If the initial tumor cell (or group of tumor cells) is not removed by the immune system, it will develop into cancer.

  • NCI Center For Cancer Research
    U.S. government resource which provides access to information for researchers and about collaborations. Aimed at the professional level.
  • NetCancerAlert
    Provides access to articles and links which are oncology related.
  • DIPEx: Cancer
    Includes audio and video interviews of patient experiences.
  • CancerEducation
    Disseminates educational programming in a multimedia electronic clips format. Aimed at both a lay and professional audience.
  • The Cancer Letter
    Periodical which supplies news and current information about the state of research and treatment.