Squamous cell cancer
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In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:
- Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
- Altered morphology.
- Building of cellular clusters (Foci).
- Loss of contact inhibition.
- Low or no need for growth factors.
Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.
In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.
Cancers are capable of spreading through the body by two mechanisms: local invasion and distant metastasis. Invasion refers to the direct migration and penetration by cancer cells into neighboring tissues. Metastasis refers to the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through the bloodstream, and then invade normal tissues elsewhere in the body. Cancer is most deadly when it metastasizes.
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A detailed review of this subject in pdf format aimed at the professional level. - NCI Center For Cancer Research
U.S. government resource which provides access to information for researchers and about collaborations. Aimed at the professional level. - About.com: Cancer
Presents general overview information on many of the main kinds of tumors. Includes news, doctor search, glossary and access to support hotlines. - Meds.com: Cancer Glossary
Aims to provide a better understanding of words frequently used in patient care. - Target Tumors
Information about targeted therapy approach in relation to a number of solid tumors.