Symptoms of ovarian cancer
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Treatment of cancer typically involves surgery to remove tumors and nearby lymph nodes to which the cancer may have spread, combined with radiation therapy and/or chemotherapy. The latter two target cells in the body that are rapidly dividing. This includes the cancer cells but also certain healthy ones, which is the reason for the severe side effects of these treatments.
For most of the cancers, it cannot be told which event was the initial cause. However, with molecular biology, it is possible to characterize the mutations within a tumor, and to a certain extent predict its behavior. For example, about half of the tumors are deficient in the tumor suppressor gene p53, also known as "the guardian of the genome". This is associated with poor prospects for the patient, since those tumor cells are unlikely to go into apoptosis (programmed cell death) after they are damaged by therapy. There are more mutations that make a tumor more malignant. Telomerase mutations enable a tumor cell to divide indefinitely. Other mutations enable the tumor to grow new blood vessels to feed it, or to detach from the surrounding tissue, spreading to other parts of the body.
Cancers are capable of spreading through the body by two mechanisms: local invasion and distant metastasis. Invasion refers to the direct migration and penetration by cancer cells into neighboring tissues. Metastasis refers to the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through the bloodstream, and then invade normal tissues elsewhere in the body. Cancer is most deadly when it metastasizes.
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- CancerEducation
Disseminates educational programming in a multimedia electronic clips format. Aimed at both a lay and professional audience. - Wikicities: Cancer
An open-publishing wiki portal for those interested in this topic. Available for viewing or editing. - CancerExperts MD
Physcians located in Boston offer second opinions and personalized case reviews. Provides an online ask-a-doctor service. - The "Y" Cancer Foundation
AOL discussion group aimed at providing information and support. - InteliHealth: Cancer
Medical information, articles and news covering a variety of tumors and related issues.