Symptoms of pancreatic cancer

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Treatment of cancer typically involves surgery to remove tumors and nearby lymph nodes to which the cancer may have spread, combined with radiation therapy and/or chemotherapy. The latter two target cells in the body that are rapidly dividing. This includes the cancer cells but also certain healthy ones, which is the reason for the severe side effects of these treatments.

In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:

Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
Altered morphology.
Building of cellular clusters (Foci).
Loss of contact inhibition.
Low or no need for growth factors.

Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.

Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.

Chemotherapy-Induced Nausea And Vomiting
A detailed review of this subject in pdf format aimed at the professional level.
The Cancer Letter
Periodical which supplies news and current information about the state of research and treatment.
COX-2 Inhibitors: Cancer
Information about these treatment agents which is based on an educational grant from the Pharmacia company.
NetCancerAlert
Provides access to articles and links which are oncology related.
Cancer Information Services
Information from the U.S. National Cancer Institute including access to links, press releases and publications.

Symptoms of pancreatic cancer