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The field of medicine concerned with the treatment of cancer is oncology. Cancer has become an important problem with the rise in life expectancy, as the abovementioned mutations become more likely the longer a person lives. Though great progress in treatment has been made, most cancers in advanced stages remain incurable and ultimately fatal.

In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:

  • Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
  • Altered morphology.
  • Building of cellular clusters (Foci).
  • Loss of contact inhibition.
  • Low or no need for growth factors.

Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.

In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.

  • CancerDirect
    Patient consultation service offering treatment advice, online second opinions and oncologist referral for individual disease.
  • Cancer Dictionary & Acronyms
    Terminology and abbreviations presented in a searchable format.
  • CancerSupportChat.org
    Presents access to online discussion, chat and support.
  • Shirley's Wellness Cafe
    Promotes holistic and alternative approaches for cancer prevention and treatment.
  • NetCancerAlert
    Provides access to articles and links which are oncology related.