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Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.
Cancer is, ultimately, a disease of genes. Typically, a series of several mutations is required before a cell becomes a cancer cell. We distinguish between oncogenes, which promote cancer when "switched on" by a mutation, and tumor suppressor genes, which prevent cancer unless "switched off" by a mutation. These mutations can have various causes: radiation or chemicals called carcinogens; some inherited predisposition is not uncommon; some viruses that can cause cancer have also been described. Usually, they carry in their genome some oncogene or tumor suppressor inactivating gene. In about 15% of all cancers, viruses seem to play a role; Bacteria, like Helicobacter pylori, also induce carcinogenesis by a process of chronic inflammation. Finally, damage by free radicals, which are a natural by-product of oxygen metabolism, can cause mutations in the DNA.
Malignant tumors such as carcinoma or sarcoma, lymphoma or leukemia originate from a cell or a group of cells in a multicellular organism that has several distinct properties:
- evading apoptosis
- Unlimited Growth Potential
- self-sufficiency of growth factors
- insensitivity to anti-growth factors
- increased cell division rate
- altered differentiation (specialization) ability
- no ability for contact inhibition
- ability to invade neighbouring tissue
- ability to build metastases
- ability to promote blood vessel growth (angiogenesis)
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- CancerFit
Details the activities of a program at the Sedona Racquet Club in Arizona. Designed to help survivors maintain good physical, emotional and spiritual fitness. - Chemotherapy-Induced Nausea And Vomiting
A detailed review of this subject in pdf format aimed at the professional level. - Nature: Cancer Update
Service which provides access to news articles and reports about recent research activity. Registration required. - Manage CINV
Offers patients and professionals information about chemotherapy-induced nausea and vomiting. - CancerSupport UK
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