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In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:
- Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
- Altered morphology.
- Building of cellular clusters (Foci).
- Loss of contact inhibition.
- Low or no need for growth factors.
Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.
In medicine, cancer is a general term for any of a number of different diseases where some of the body's own cells divide in an uncontrolled manner. The resulting new cells can form a malignant tumor (a neoplasm) or propagate throughout the body.
The term cancer is very broad and covers many different illnesses including:
- Carcinoma (arising from epithelial cells)
- Bladder carcinoma
- Breast cancer
- Cervical cancer
- Colorectal cancer (includes colon, rectum, anus, and appendix)
- Esophageal cancer
- Endometrial cancer (uterus)
- Hepatocellular carcinoma (liver)
- Laryngeal cancer
- Lung cancer
- Oral cancer
- Ovarian cancer
- Pancreatic cancer
- Prostate cancer
- Renal cell carcinoma (kidney)
- Skin cancer
- Stomach cancer
- Testicular cancer
- Thyroid cancer
- Sarcoma (arising from connective tissue and related)
- Gastrointestinal stromal cell tumor (GIST)
- Rhabdomyosarcoma (muscle)
- Osteosarcoma (bone)
- Hematological malignancies (blood and bone marrow)
- Leukemia
- Lymphomas
- Hodgkin's disease
- Non-Hodgkin's lymphoma
- Multiple myeloma
- Miscellaneous
- Brain tumor
- Melanoma, Moles and dysplastic nevi
- Teratoma
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- CancerCare
Topics of interest to patients and their families including treatment side-effects, pain control, nutrition and bereavement. - Hologuides: Cancer
Information about various tumors in a links format. - Rare Adult & Pediatric Cancers
Provides information, support, forums, links and news. - Cancer Chart
Quick reference listing of the most common tumor types. - CancerEducation
Disseminates educational programming in a multimedia electronic clips format. Aimed at both a lay and professional audience.