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Even when the techniques used are not scientifically proven, the pursuit of wellness can enhance health by a placebo effect. Someone who feels "well" may lower stress and enhance their sense of well-being, achieving an enhanced psychological state with proven beneficial effects on various body systems, including blood pressure, gastrointestinal system functioning, and immune response. The field of psychoneuroimmunology explores these linkages in a scientific manner, and is also a part of medicine proper. However it is new, and still exploring the biology, and has little or no clear advice to offer other than to avoid unnecessary stress or that which is out of one's control or capacity.

Wellness can include using scientifically-based tests and practices to maintain health, as in checking cholesterol, blood pressure, glucose, and other body indicators. Or it can include unproven practices, such as avoiding certain foods or taking certain vitamins or alternative medicines.

Wellness refers generally to the state of being healthy, but by the late 20th century, became, as well, a description of the interest in the more affluent nations to adopt behaviors which prolong and enhance the state of being healthy, and by extension, the lifespan itself.