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Even when the techniques used are not scientifically proven, the pursuit of wellness can enhance health by a placebo effect. Someone who feels "well" may lower stress and enhance their sense of well-being, achieving an enhanced psychological state with proven beneficial effects on various body systems, including blood pressure, gastrointestinal system functioning, and immune response. The field of psychoneuroimmunology explores these linkages in a scientific manner, and is also a part of medicine proper. However it is new, and still exploring the biology, and has little or no clear advice to offer other than to avoid unnecessary stress or that which is out of one's control or capacity.

Wellness, as a concept and a practice, is found in more affluent societies because it involves managing the body state after the more basic needs of food, shelter and basic medical care have already been met. Many of the practices applied in the pursuit of wellness, in fact, are aimed at controlling the side effects of affluence, such as obesity and inactivity - leading to lack of exercise.

Wellness can include using scientifically-based tests and practices to maintain health, as in checking cholesterol, blood pressure, glucose, and other body indicators. Or it can include unproven practices, such as avoiding certain foods or taking certain vitamins or alternative medicines.