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Even when the techniques used are not scientifically proven, the pursuit of wellness can enhance health by a placebo effect. Someone who feels "well" may lower stress and enhance their sense of well-being, achieving an enhanced psychological state with proven beneficial effects on various body systems, including blood pressure, gastrointestinal system functioning, and immune response. The field of psychoneuroimmunology explores these linkages in a scientific manner, and is also a part of medicine proper. However it is new, and still exploring the biology, and has little or no clear advice to offer other than to avoid unnecessary stress or that which is out of one's control or capacity.

Wellness refers generally to the state of being healthy, but by the late 20th century, became, as well, a description of the interest in the more affluent nations to adopt behaviors which prolong and enhance the state of being healthy, and by extension, the lifespan itself.

Wellness, in this sense, is subjective, the perception of being healthy, rather than any investigatable "reality" of being healthy. The behaviors in the pursuit of wellness sometimes include proven methodologies, but may also include practices with no scientifically proven capacity to increase health.