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The most solid aspects of wellness that fit firmly in the realm of medicine are the environmental health, nutrition, disease prevention, and public health matters that can be investigated and assist in measuring well-being.

Even when the techniques used are not scientifically proven, the pursuit of wellness can enhance health by a placebo effect. Someone who feels "well" may lower stress and enhance their sense of well-being, achieving an enhanced psychological state with proven beneficial effects on various body systems, including blood pressure, gastrointestinal system functioning, and immune response. The field of psychoneuroimmunology explores these linkages in a scientific manner, and is also a part of medicine proper. However it is new, and still exploring the biology, and has little or no clear advice to offer other than to avoid unnecessary stress or that which is out of one's control or capacity.

Wellness grew as a popular concept starting in the late 19th century, just as the middle class began emerging in the industrialized world, and a time when a newly prosperous public had the time and the resources to pursue wellness and other forms of self-improvement. Many early consumer products, from corn flakes to mouth wash, derived from or exploited the emerging interest in wellness.