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Even when the techniques used are not scientifically proven, the pursuit of wellness can enhance health by a placebo effect. Someone who feels "well" may lower stress and enhance their sense of well-being, achieving an enhanced psychological state with proven beneficial effects on various body systems, including blood pressure, gastrointestinal system functioning, and immune response. The field of psychoneuroimmunology explores these linkages in a scientific manner, and is also a part of medicine proper. However it is new, and still exploring the biology, and has little or no clear advice to offer other than to avoid unnecessary stress or that which is out of one's control or capacity.

Wellness is thought by most to be closely related to wealth, either because one must control resources to avoid stress, or because wealth itself cannot be enjoyed unless one is well, and therefore one can be potentially both in command of resources and suffering a sort of sensual or stressful poverty at one and the same time. It is sometimes observed that even rich people who take on too many commitments often have just as little free time as the poor - and may very easily outrun their resources.

Wellness can include using scientifically-based tests and practices to maintain health, as in checking cholesterol, blood pressure, glucose, and other body indicators. Or it can include unproven practices, such as avoiding certain foods or taking certain vitamins or alternative medicines.