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When a person has been in contact with poison ivy, there are several measures that may be taken to prevent or lessen a rash. Zanfel and Tecnu are commercial preparations designed to 'unlock' urishiol from the skin. If applied within 20 minutes of exposure to poison ivy, these may be effective in completely preventing an outbreak. Zanfel, the more expensive of the two by far, is said to be effective at any stage of a poison ivy outbreak.

Virginia creeper, Parthenocissus quinquefolia, vine can look like poison ivy. The younger leaves can come in groups of three but have a few more serrations along the leaf edge, and the leaf surface is somewhat wrinkled. Virginia creeper and poison ivy very often grow together, even on the same tree.

Poison ivy grows vigorously throughout much of North America, but particularly in the American Midwest. It can grow as a shrub up to about four feet tall, or as a groundcover four to ten inches high, or as a climbing vine on any and every support. Older vines on substantial supports send out lateral branches that may at first be mistaken for tree limbs.

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