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Preventing exposure to poison ivy involves ways of preventing the oil from getting on the skin. - Wear long clothing, avoid any plants that look like poison ivy. - If you must wear short clothing, put thick lotion on areas that may be exposed to poison ivy, like the legs. A suntan oil may work even better. - If you handle tools that have touched it, wear gloves, then wipe the tools with alcohol immediately after using them, or throw them away.

An unfortunate story, often repeated, is that "Wherever poison ivy is found, jewelweed grows close by." This is completely untrue; poison ivy grows in a wide variety of habitats, while jewelweed is restricted to moist bottomlands and valleys with rich soil. The reverse is true — wherever jewelweed is found, poison ivy is usually close by. Jewelweed grows in sunny wet areas, like ditches on the roadside. The 1 cm (1/2 inch) long flowers are shaped like a shoe. Some plants have orange flowers with dark spots. Some plants have plain yellow flowers.

Normally, it takes about twenty-four hours for the rash to first appear, though it may worsen during the next few days and may appear to spread, when in fact what is happening is that areas that received a lesser dose are latently reacting. The rash takes one to two weeks to run its course, but normally does not leave scars. Severe cases will have small (1-2mm) white fluid-filled blisters on the skin.