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Another method is to take mud, preferably clay mud, and vigorously rub it in. Affected people can also use either laundry detergents or strong soap to scrub the area before the rash appears.

The skin rash, featuring fluid-filled blisters and reddened areas that itch intensely, is caused by an irritating oil, urushiol. Urushiol binds to skin cell walls, changing their configuration, so that the body's immune system no longer recognizes these cells as belonging to the body and attacks them as foreign. Some people are susceptible to the rash, and others aren't, but reactions can change during a person's lifetime. Someone who was formerly not subject to it may become very sensitive, and vice versa.

If the poison ivy is growing up a tree look at the fine. It will be smooth with no ladder like roots clinging to the tree. (Some sources report that poison ivy does have these ladder like roots.)

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