Symptoms of bone cancer

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Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.

For most of the cancers, it cannot be told which event was the initial cause. However, with molecular biology, it is possible to characterize the mutations within a tumor, and to a certain extent predict its behavior. For example, about half of the tumors are deficient in the tumor suppressor gene p53, also known as "the guardian of the genome". This is associated with poor prospects for the patient, since those tumor cells are unlikely to go into apoptosis (programmed cell death) after they are damaged by therapy. There are more mutations that make a tumor more malignant. Telomerase mutations enable a tumor cell to divide indefinitely. Other mutations enable the tumor to grow new blood vessels to feed it, or to detach from the surrounding tissue, spreading to other parts of the body.

Cancers are capable of spreading through the body by two mechanisms: local invasion and distant metastasis. Invasion refers to the direct migration and penetration by cancer cells into neighboring tissues. Metastasis refers to the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through the bloodstream, and then invade normal tissues elsewhere in the body. Cancer is most deadly when it metastasizes.

Cancer Matters
Contains information, treatment options, and resources on a range of cancers. Also includes links to general resources, and a directory of services and resources located in a number of US cities.
CancerLinks.org
Resources about the condition and treatment in a links format.
Yahoo Health: Chemotherapy Center
Information on chemotherapy including basic facts, what to expect, side effects and a FAQ.
On Top Of Cancer
Links-based guide to Internet resource.
Cancer Chart
Quick reference listing of the most common tumor types.

Symptoms of bone cancer