Squamous cell cancer

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In cellular model systems, cells are exposed to carcinogenic influences (chemicals, radiation). In these systems, the first signs of a cell developing into a tumor cell are:

Immortality. The usual number of cell divisions for a mammalian cell is 50-60 (cell senescence), then it ceases to divide. Tumor cells keep dividing forever.
Altered morphology.
Building of cellular clusters (Foci).
Loss of contact inhibition.
Low or no need for growth factors.

Items 2-4 (above) can sometimes be traced to mutations in genes that result in a disruption of cell adhesion. Some cell adhesion proteins are oncogenes.

Carcinogenesis (lit.: creation of cancer) is the process of derangement of the rate of cell division.

Cancers are capable of spreading through the body by two mechanisms: local invasion and distant metastasis. Invasion refers to the direct migration and penetration by cancer cells into neighboring tissues. Metastasis refers to the ability of cancer cells to penetrate into lymphatic and blood vessels, circulate through the bloodstream, and then invade normal tissues elsewhere in the body. Cancer is most deadly when it metastasizes.

CancerNausea.com
Presents information to help manage nausea and vomiting caused by chemotherapy or radiation treatments.
InteliHealth: Cancer
Medical information, articles and news covering a variety of tumors and related issues.
Suite 101
Articles and links about cancer treatments.
AllExperts Oncology Q&A
Comprehensive directory of cancer experts volunteering to answer both general and disease-specific questions.
The Cancer Supportive Care Programs
Book excerpts covering such topics as psychosocial issues, support, nutrition, pain control and spirituality.

Squamous cell cancer