High cholesterol

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In conditions featuring elevated LDL, cholesterol often forms plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease.

Cholesterol is primarily synthesized from acetyl CoA through the HMG-CoA reductase pathway in the liver (~1 g/day), although other sites include the intestines, adrenal glands and reproductive organs.

The American Heart Association provides a set of guidelines for total (fasting) blood cholesterol levels and risk for heart disease:

Level mg/dl Level mmol/L Interpretation
<200 <5.2 Desirable level corresponding to lower risk for heart disease
200-239 5.2-6.2 Borderline high risk
>240 >6.2 High risk

Ask The Dietitian
Question and answer format about cholesterol and saturated fat.
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High cholesterol, lipids, lipoproteins, LDL HDL, triglycerides, and metabolic syndrome. Offers answers as to what it all means, and how to treat it.
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Information for understanding the facts and reducing your risk factor of heart disease and stroke. Recipes available.
Veritas Medicine
Clinical trial listings for high cholesterol. Perform a personalized search to find ongoing clinical trials that match your needs.
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Information about genetically-caused heart disease due to small-particle LDL syndrome. Includes questions and answers, book excerpt and cardiac risk quiz.

High cholesterol